台湾一项基于人群的骨质疏松症与牙周炎风险的5年随访研究。
Population-based 5-year follow-up study in Taiwan of osteoporosis and risk of periodontitis.
作者信息
Chang Wei-Pin, Chang Wei-Chiao, Wu Mei-Shin, Pai Jei-Tsung, Guo Yuh-Cherng, Chen Ku-Chung, Liu Mu-En, Chiu Wen-Ta, Hung Kuo-Sheng
机构信息
Department of Healthcare Management, Yuanpei University, HsinChu, Taiwan.
出版信息
J Periodontol. 2014 Mar;85(3):e24-30. doi: 10.1902/jop.2013.130256. Epub 2013 Sep 3.
BACKGROUND
Osteoporosis and periodontitis are both considered global health issues that threaten postmenopausal women and the older population. However, the correlation between osteoporosis and periodontitis is still unclear.
METHODS
Using a nationwide Taiwanese population-based database, data from patients with osteoporosis (2003 to 2005; n = 2,527) and 7,575 individuals who were matched to each patient by age and sex were analyzed. All participants were tracked for 5 years from the date of enrollment to observe the percentage of patients who developed periodontitis. Cox proportional hazard regressions were performed to evaluate 5-year periodontitis-free survival rates.
RESULTS
Among the total sample, 3,060 individuals were diagnosed with periodontitis during the 5-year follow-up period: 792 in the study cohort and 2,268 in the comparison cohort. The adjusted hazard ratio for periodontitis in patients with osteoporosis compared with individuals without osteoporosis during the 5-year follow-up was 1.14 (95% confidence interval = 1.05 to 1.24, P <0.01).
CONCLUSION
This population-based study indicated that patients with osteoporosis may have an increased risk of periodontitis.
背景
骨质疏松症和牙周炎均被视为威胁绝经后女性及老年人群的全球性健康问题。然而，骨质疏松症与牙周炎之间的相关性仍不明确。
方法
利用全台湾基于人群的数据库，分析了骨质疏松症患者（2003年至2005年；n = 2527）的数据以及7575名按年龄和性别与每位患者匹配的个体的数据。从入组日期起对所有参与者进行5年跟踪，以观察发生牙周炎的患者百分比。进行Cox比例风险回归分析以评估5年无牙周炎生存率。
结果
在整个样本中，3060名个体在5年随访期内被诊断为牙周炎：研究队列中有792名，对照队列中有2268名。在5年随访期间，骨质疏松症患者发生牙周炎的调整后风险比与无骨质疏松症个体相比为1.14（95%置信区间 = 1.05至1.24，P <0.01）。
结论
这项基于人群的研究表明，骨质疏松症患者患牙周炎的风险可能增加。
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