牙龈炎和牙周炎患者的癌症风险：一项全国性队列研究。

Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study.

机构信息

M.D., Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan.

出版信息

QJM. 2014 Apr;107(4):283-90. doi: 10.1093/qjmed/hct248. Epub 2013 Dec 11.

DOI:10.1093/qjmed/hct248

PMID:24336850

Abstract

AIM

Periodontal disease encompasses gingivitis and periodontitis, which exerts systemic effects. We conducted a population-based study to evaluate the association between periodontal disease and the risk of cancer.

METHODS

We used insurance claims data from 1997 to 2010, accessing a database of 1 million randomly selected insurants in Taiwan. All patients were older than 20 and newly diagnosed with periodontitis between 1 January 1997 and 31 December 2010. The comparison cohort comprised patients older than 20, who were newly diagnosed with gingivitis in the same period. Both cohorts were followed until a cancer diagnosis, lost to follow-up, death, termination of insurance, or the end of 2010.

RESULTS

The incidence rate of cancer was 1.14 times higher in the study cohort than in the comparison cohort [confidence interval (CI) = 1.11-1.17]. The adjusted hazard ratio (HR) was 1.05 (95% CI = 1.00-1.11). A multivariable analysis showed that the periodontitis patients exhibited an elevated risk of developing oral cancer (adjusted HR = 1.79, 95% CI = 1.42-2.25).

CONCLUSION

The findings indicated that patients in the periodontitis cohort exhibited a higher risk of developing oral cancer than those in the gingivitis cohort.

摘要

目的

牙周病包括牙龈炎和牙周炎，会产生全身性影响。我们进行了一项基于人群的研究，以评估牙周病与癌症风险之间的关系。

方法

我们使用了 1997 年至 2010 年的保险理赔数据，访问了台湾 100 万随机参保人的数据库。所有患者年龄均大于 20 岁，并且在 1997 年 1 月 1 日至 2010 年 12 月 31 日期间被新诊断为牙周炎。对照组由在同期被新诊断为牙龈炎且年龄大于 20 岁的患者组成。两个队列均随访至癌症诊断、失访、死亡、保险终止或 2010 年底。