再探受体运输假说：在已确立的癫痫持续状态期间 AMPA 受体的可塑性。
Receptor trafficking hypothesis revisited: plasticity of AMPA receptors during established status epilepticus.
机构信息
Department of Neurology, University of Virginia, Health Sciences Center, Charlottesville, VA, U.S.A.
出版信息
Epilepsia. 2013 Sep;54 Suppl 6:14-6. doi: 10.1111/epi.12266.
Status epilepticus (SE) is associated with a dynamic plasticity of postsynaptic neurotransmitter receptors. The plasticity of AMPA receptor (AMPAR)-mediated glutamatergic transmission during established SE (ESE), after development of benzodiazepine resistance, was evaluated. There was increased frequency and inward rectification of AMPAR-mediated excitatory postsynaptic currents at Schaffer collateral - CA1 pyramidal neuron synapses during ESE. Surface expression of the GluA1 subunit increased, and this was a consequence of N-methyl-d-aspartate receptor activation. Further, diminishing glutamate release by activation of somatostatin receptors prevented SE. These studies suggest that AMPAR-mediated glutamatergic transmission is strengthened during ESE.
癫痫持续状态（SE）与突触后神经递质受体的动态可塑性有关。在苯二氮䓬类药物耐药后建立的 SE（ESE）期间，评估了 AMPA 受体（AMPAR）-介导的谷氨酸能传递的可塑性。在 ESE 期间，Schaffer 侧枝-CA1 锥体神经元突触处 AMPAR 介导的兴奋性突触后电流的频率和内向整流增加。GluA1 亚基的表面表达增加，这是 N-甲基-D-天冬氨酸受体激活的结果。此外，通过激活生长抑素受体减少谷氨酸释放可防止 SE。这些研究表明，在 ESE 期间 AMPAR 介导的谷氨酸能传递增强。
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