Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Strubergasse 21, Salzburg, Austria.
Epilepsia. 2013 Sep;54 Suppl 6:40-2. doi: 10.1111/epi.12274.
Neurogenesis in the adult central nervous system has been well documented in several mammals including humans. By now, a plethora of data has been generated with the aim of understanding the molecular and cellular events governing neurogenesis. This growing comprehension will provide the basis for modulation of neurogenesis for therapeutic purposes, in particular in neurodegenerative diseases. Herein, we review the current knowledge on neurogenesis, in particular in the frame of epilepsy, since seizures have massive effects on neurogenesis. Conversely, some studies have suggested that aberrant neurogenesis might contribute to the development or manifestation of epilepsy and, moreover, chronic inhibition of neurogenesis in epilepsy might contribute to comorbidities of epilepsy such as cognitive deficits. Therefore, a better understanding of neurogenesis in the context of epilepsy is still required for future therapeutic purposes.
成年中枢神经系统中的神经发生在包括人类在内的几种哺乳动物中已有充分的记录。到目前为止，已经产生了大量的数据，旨在了解控制神经发生的分子和细胞事件。这种不断增长的理解将为神经发生的调节提供基础，特别是在神经退行性疾病方面。在此，我们综述了神经发生的最新知识，特别是在癫痫的框架内，因为癫痫发作对神经发生有巨大的影响。相反，一些研究表明，异常的神经发生可能有助于癫痫的发展或表现，此外，癫痫中神经发生的慢性抑制可能导致癫痫的合并症，如认知缺陷。因此，为了未来的治疗目的，仍需要在癫痫背景下更好地了解神经发生。
