自身免疫、癫痫发作和癫痫持续状态。
Autoimmunity, seizures, and status epilepticus.
机构信息
Department of Neurology, University of Pennsylvania, Philadelphia, PA, U.S.A.
出版信息
Epilepsia. 2013 Sep;54 Suppl 6(0 6):46-9. doi: 10.1111/epi.12276.
Abstract
The recent discovery of a category of autoimmune encephalitis associated with antibodies against neuronal cell-surface and synaptic proteins has renewed interest for autoimmune causes of epilepsy. The identification of autoimmune encephalitis has changed paradigms in the diagnosis and management of several novel and treatable syndromes that occur with seizures and status epilepticus previously attributed to viral or idiopathic etiologies. This review focuses on the novel group of autoimmune encephalitis and also discusses some classical paraneoplastic syndromes that constitute another group of autoimmune disorders that may result in seizures.
摘要
最近发现了一类与神经元细胞表面和突触蛋白抗体相关的自身免疫性脑炎，这重新引起了人们对癫痫的自身免疫性病因的关注。自身免疫性脑炎的鉴定改变了几种新的和可治疗的综合征的诊断和治疗模式，这些综合征以前归因于病毒或特发性病因，伴有癫痫发作和癫痫持续状态。这篇综述重点介绍了新型自身免疫性脑炎，并讨论了一些经典的副肿瘤综合征，它们构成了另一组可能导致癫痫的自身免疫性疾病。
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