UCL Institute of Neurology, University College London, Queen Street, London, UK.
Epilepsia. 2013 Sep;54 Suppl 6:64-7. doi: 10.1111/epi.12281.
The evolution of the treatment of convulsive status epilepticus since the mid- nineteenth century is outlined. Therapy has been advanced not only by the use of new drugs, but also by advances in the approach to therapy. The major pharmacologic developments were the introductions of bromide, anesthetics, barbiturate, phenytoin, paraldehyde, chlormethiazole, and the benzodiazepines. Throughout this period, the emphasis of therapy was on "sedation" and anesthesia, and the development of technologies for safe anesthesia in the postwar years were an important step. Since 1970, changes to the approach to therapy have been more important than any pharmacologic advance, and it is only recently that new drugs have been introduced into the therapy of status epilepticus. We may now be on the threshold of significant new paradigm shifts.
自 19 世纪中叶以来，癫痫持续状态治疗的演变情况概述如下。治疗方法的进步不仅得益于新药的应用，还得益于治疗方法的改进。主要的药物学进展包括溴化物、麻醉剂、巴比妥类、苯妥英钠、水合氯醛、氯甲噻唑和苯二氮䓬类的引入。在此期间，治疗的重点一直是“镇静”和麻醉，战后安全麻醉技术的发展是重要的一步。自 1970 年以来，治疗方法的改变比任何药物学进展都更为重要，直到最近才将新药引入癫痫持续状态的治疗中。我们现在可能正处于重大范式转变的门槛上。
