Department of Neurology of the Ludolf Krehl Clinic, University of Heidelberg, Heidelberg, Germany.
Epilepsia. 2013 Sep;54 Suppl 6:3-10. doi: 10.1111/epi.12264.
The treatment of status epilepticus has changed over the past five decades since the first colloquium on status epilepticus, held in Marseille in 1962. New intravenous drugs, such as valproate, levetiracetam, lacosomide or ketamine and new routes of administration, such as intranasal or bucal, as well as high-class randomized clinical trials in the prehospital setting and early stages of status have changed the field. However it is remarkable, how the basic principles and difficulties of treatment of status epilepticus have remained the same. This article is as a translation of a narrative review authored by Dieter Janz at the Marseille Colloquium 1962, published in 1967. The medical practice and all available treatment at that time have been reviewed critically in the article. The translation of the original French article has been kept as close as possible to the original, to give a detailed account on the treatment of status at that time.
自 1962 年在马赛举行第一次癫痫持续状态学术研讨会以来，过去五十年间癫痫持续状态的治疗已经发生了变化。新的静脉内药物，如丙戊酸钠、左乙拉西坦、拉科酰胺或氯胺酮，以及新的给药途径，如鼻内或口腔内，以及在院前环境和癫痫持续状态早期进行的高级随机临床试验，都改变了这一领域。然而，令人惊讶的是，癫痫持续状态的治疗基本原则和困难仍然相同。本文是 1962 年马赛学术研讨会作者迪特尔·扬茨（Dieter Janz）撰写的一篇叙述性综述的译文，发表于 1967 年。本文对当时的医疗实践和所有可用的治疗方法进行了批判性回顾。对原文的法译版进行了尽可能忠实的翻译，以详细说明当时的癫痫持续状态的治疗方法。
