Conradt Elisabeth, Abar Beau, Sheinkopf Stephen, Lester Barry, Lagasse Linda, Seifer Ronald, Shankaran Seetha, Bada-Ellzey Henrietta, Bauer Charles, Whitaker Toni, Hinckley Matt, Hammond Jane, Higgins Rosemary
Department of Pediatrics, Women and Infants Hospital of Rhode Island, Brown Center for the study of Children at Risk; Department of Psychiatry, Warren Alpert Medical School of Brown University.
Dev Psychobiol. 2014 May;56(4):821-35. doi: 10.1002/dev.21155. Epub 2013 Sep 3.
We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.
我们采用潜在生长曲线分析，以研究不同产前物质暴露水平和早期逆境的儿童在3至6岁期间呼吸性窦性心律不齐（RSA）的轨迹。数据来自一项关于产前物质暴露的前瞻性纵向研究，该研究包括1121名参与者。在3岁、4岁、5岁和6岁时评估基线RSA以及RSA对一项需要注意力的任务的反应性。总体而言，在整个发育过程中，RSA反应性的轨迹存在显著个体差异，但基线RSA不存在个体差异。更高水平的产前物质暴露和更少的早期逆境暴露与3岁时RSA反应性增加有关，但到6岁时，两者都与更高的RSA反应性有关。产前物质暴露通过早期逆境对RSA反应性的增长产生间接影响。结果支持并有助于应激负荷框架。
