Huang Keng-Shiang, Yang Chih-Hui, Kung Chao-Ping, Grumezescu Alexandru Mihai, Ker Ming-Dou, Lin Yung-Sheng, Wang Chih-Yu
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Taiwan.
Electrophoresis. 2014 Feb;35(2-3):330-6. doi: 10.1002/elps.201300194. Epub 2013 Oct 18.
A core-shell gelatin-alginate composite used for intestine-released oral delivery drug carrier was synthesized through microfluidic technique. At the fixed continuous phase flow rate, the size of the core-shell gelatin-alginate microparticles increases with the dispersed phase flow rate, and monodispersity can be retained (the variation coefficient for the diameter distribution can be kept less than 10%). The fabricated microparticles could remain intact in gastric juice for at least 3 h, indicating that the gelatin core could be well protected by alginate shell in acid environment. However, the alginate shell of the microparticles would swell or collapse in alkali environment in half an hour, assuring the controlled drug release in intestinal juice. The fabricated uniform core-shell gelatin-alginate microparticles were potential as pH-responsive drug carriers.
通过微流控技术合成了一种用于肠道释放口服给药载体的核壳明胶-海藻酸盐复合材料。在固定的连续相流速下，核壳明胶-海藻酸盐微粒的尺寸随分散相流速的增加而增大，并且可以保持单分散性（直径分布的变异系数可保持小于10%）。制备的微粒在胃液中至少能保持完整3小时，这表明在酸性环境中，明胶核可被海藻酸盐壳很好地保护。然而，微粒的海藻酸盐壳在碱性环境中半小时内会膨胀或崩解，从而确保在肠液中药物的可控释放。制备的均匀核壳明胶-海藻酸盐微粒有潜力作为pH响应性药物载体。
