Korablev V N
Antibiot Khimioter. 1990 Jun;35(6):45-6.
Isoniazid pharmacokinetics was studied in 93 patients with pulmonary tuberculosis including 47 patients with concomitant chronicTrematode infection. After enteral administration of the drug its blood concentrations were shown to be low due to the decreased absorption function of the small intestine and impaired absorption and excretion functions of the hepatobiliary system. It was concluded that in such patients intramuscular administration of isoniazid was advisable.
对93例肺结核患者（包括47例合并慢性吸虫感染的患者）进行了异烟肼药代动力学研究。经肠道给药后，由于小肠吸收功能下降以及肝胆系统吸收和排泄功能受损，其血药浓度较低。得出的结论是，在此类患者中，建议采用异烟肼肌肉注射。
