Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, F-67084 Strasbourg, France.
Cold Spring Harb Perspect Med. 2013 Sep 1;3(9):a010298. doi: 10.1101/cshperspect.a010298.
Pathogenic bacteria possess intricate regulatory networks that temporally control the production of virulence factors, and enable the bacteria to survive and proliferate after host infection. Regulatory RNAs are now recognized as important components of these networks, and their study may not only identify new approaches to combat infectious diseases but also reveal new general control mechanisms involved in bacterial gene expression. In this review, we illustrate the diversity of regulatory RNAs in bacterial pathogens, their mechanism of action, and how they can be integrated into the regulatory circuits that govern virulence-factor production.
致病菌拥有复杂的调控网络，这些网络可对毒力因子的产生进行时间控制，使细菌在感染宿主后能够存活和增殖。现在，调控 RNA 被认为是这些网络的重要组成部分，对其进行研究不仅可能为防治传染病提供新的方法，还可能揭示参与细菌基因表达的一般性调控机制。在这篇综述中，我们阐述了细菌致病菌中调控 RNA 的多样性、它们的作用机制，以及它们如何整合到调控毒力因子产生的调控回路中。
