Akbulut Sabiye, Gür Günes, Topal Firdevs, Senel Engin, Topal Fatih Esad, Alli Nuran, Saritas Ulkü
Department of Gastroenterology, Kartal Kosuyolu High Speciality Education and Research Hospital, Istanbul, Turkey.
Ann Dermatol. 2013 Aug;25(3):298-303. doi: 10.5021/ad.2013.25.3.298. Epub 2013 Aug 13.
The possible relationship between psoriasis and coeliac disease (CD) has been attributed to the common pathogenic mechanisms of the two diseases and the presence of antigliadin antibodies in patients has been reported to increase the incidence of CD.
The aim of this report was to study CD-associated antibodies serum antigliadin antibody immunoglobulin (Ig)A, IgG, anti-endomysial antibody IgA and anti-transglutaminase antibody IgA and to demonstrate whether there is an increase in the frequency of those markers of CD in patients with psoriasis.
Serum antigliadin antibody IgG and IgA, antiendomysial antibody IgA and anti-transglutaminase antibody IgA were studied in 37 (19 males) patients with psoriasis and 50 (23 males) healthy controls. Upper gastrointestinal endoscopy and duodenal biopsies were performed in patients with at least one positive marker.
Antigliadin IgA was statistically higher in the psoriasis group than in the controls (p<0.05). Serological markers were found positive in 6 patients with psoriasis and 1 person from the control group. Upper gastrointestinal endoscopy was performed in all these persons, with biopsies collected from the duodenum. The diagnosis of CD was reported in only one patient with psoriasis following the pathological examination of the biopsies. Whereas one person of the control group was found to be positive for antigliadin antibody IgA, pathological examination of the duodenal biopsies obtain from this patient were found to be normal.
Antigliadin IgA prominently increases in patients diagnosed with psoriasis. Patients with psoriasis should be investigated for latent CD and should be followed up.
银屑病与乳糜泻（CD）之间可能的关系归因于这两种疾病共同的致病机制，并且据报道患者体内抗麦醇溶蛋白抗体的存在会增加CD的发病率。
本报告旨在研究与CD相关的抗体，血清抗麦醇溶蛋白抗体免疫球蛋白（Ig）A、IgG、抗肌内膜抗体IgA和抗转谷氨酰胺酶抗体IgA，并证明银屑病患者中这些CD标志物的频率是否增加。
对37例（19例男性）银屑病患者和50例（23例男性）健康对照者进行血清抗麦醇溶蛋白抗体IgG和IgA、抗肌内膜抗体IgA和抗转谷氨酰胺酶抗体IgA的检测。对至少有一项阳性标志物的患者进行上消化道内镜检查和十二指肠活检。
银屑病组抗麦醇溶蛋白IgA在统计学上高于对照组（p<0.05）。在6例银屑病患者和1例对照组患者中发现血清学标志物呈阳性。对所有这些人进行了上消化道内镜检查，并从十二指肠采集了活检组织。在对活检组织进行病理检查后，仅1例银屑病患者被诊断为CD。而对照组中有1人抗麦醇溶蛋白抗体IgA呈阳性，但该患者十二指肠活检组织的病理检查结果正常。
诊断为银屑病的患者抗麦醇溶蛋白IgA显著增加。应对银屑病患者进行潜在CD的筛查并进行随访。
