Faculty of Pharmaceutical Sciences, Collaboration for Outcomes Research and Evaluation, University of British Columbia Vancouver British Columbia Canada.
BMJ Open. 2013 Sep 4;3(9):e003360. doi: 10.1136/bmjopen-2013-003360.
Many patients with asthma spend time and resources consuming complementary and alternative medicines (CAMs). This study explores whether CAM utilisation is associated with asthma control and the intake of asthma controller medications.
Population-based, prospective cross-sectional study.
General population residing in two census areas in the province of British Columbia, Canada. Recruitment was based on random-digit dialling of both landlines and cell phones.
486 patients with self-reported physician diagnosis of asthma (mean age 52 years; 67.3% woman).
We assessed CAM use over the previous 12 months, level of asthma control as defined by the Global Initiative for Asthma and the self-reported intake of controller medications. Multivariate logistic regression was performed to study the relationship between any usage of CAMs (outcome), asthma control and controller medication usage, adjusted for potential confounders.
A total of 179 (36.8%) of the sample reported CAM usage in the past 12 months. Breathing exercises (17.7%), herbal medicines (10.1%) and vitamins (9.7%) were the most popular CAMs reported. After adjustment, female sex (OR 1.66; 95% CI 1.09 to 2.52) and uncontrolled asthma (vs controlled asthma, OR 2.25, 95% CI 1.30 to 3.89) were associated with a higher likelihood of using any CAMs in the past 12 months. Controller medication use was not associated with CAM usage in general and in the subgroups defined by asthma control.
Clinicians and policy makers need to be aware of the high prevalence of CAM use in patients with asthma and its association with lack of asthma control.
许多哮喘患者花费时间和资源来使用补充和替代药物（CAM）。本研究旨在探讨 CAM 的使用是否与哮喘控制以及哮喘控制药物的摄入有关。
基于人群的前瞻性横断面研究。
加拿大不列颠哥伦比亚省两个普查区的普通人群。通过对固定电话和手机的随机数字拨号进行招募。
486 名自我报告的经医生诊断为哮喘的患者（平均年龄 52 岁；67.3%为女性）。
我们评估了过去 12 个月中 CAM 的使用情况、根据全球哮喘倡议（Global Initiative for Asthma）定义的哮喘控制水平以及自我报告的控制药物的使用情况。采用多变量逻辑回归分析方法，研究 CAM 使用（结局）与哮喘控制和控制药物使用之间的关系，同时调整了潜在的混杂因素。
共有 179 名（36.8%）患者在过去 12 个月内报告使用了 CAM。最受欢迎的 CAM 包括呼吸练习（17.7%）、草药（10.1%）和维生素（9.7%）。调整后，女性（OR 1.66；95%CI 1.09 至 2.52）和未控制的哮喘（与控制的哮喘相比，OR 2.25，95%CI 1.30 至 3.89）与过去 12 个月内使用任何 CAM 的可能性更高相关。控制药物的使用与 CAM 的使用总体上以及根据哮喘控制程度定义的亚组均无关联。
临床医生和政策制定者需要意识到哮喘患者中 CAM 使用的高患病率及其与哮喘控制不佳的关联。
