Lippert Annemarie, Renner Bertold
Institute of Clinical Pharmacology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01069 Dresden, Germany.
J Clin Med. 2022 Mar 12;11(6):1567. doi: 10.3390/jcm11061567.
Many people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible for the majority of patients, there is a growing interest in and usage of phytomedicine. Plant preparations are not only used as alternative treatment, but also combined with conventional drugs. These combinations deserve careful contemplation, as the complex mixtures of bioactive substances in plants show a potential for interactions. Induction of CYP enzymes and pGP by St John's wort may be the most famous example, but there is much more to consider. In this review, we shed light on what is known about the interactions between botanicals and drugs, in order to make practitioners aware of potential drug-related problems. The main focus of the article is the treatment of inflammatory diseases, accompanied by plant preparations used in Europe. Several of the drugs we discuss here, as basal medication in chronic inflammatory diseases (e.g., methotrexate, janus kinase inhibitors), are also used as oral tumor therapeutics.
全球许多人使用植物制剂用于医疗目的。即使在工业化地区，如欧洲，大多数患者都可获得传统疗法，但对植物药的兴趣和使用也在不断增加。植物制剂不仅用作替代疗法，还与传统药物联合使用。这些联合用药值得仔细考虑，因为植物中生物活性物质的复杂混合物显示出相互作用的可能性。圣约翰草对细胞色素P450酶（CYP）和P-糖蛋白（pGP）的诱导作用可能是最著名的例子，但还有更多需要考虑的因素。在这篇综述中，我们阐明了关于植物药与药物之间相互作用的已知情况，以使从业者意识到潜在的药物相关问题。本文的主要重点是炎症性疾病的治疗，以及欧洲使用的植物制剂。我们在此讨论的几种药物，作为慢性炎症性疾病的基础用药（如甲氨蝶呤、Janus激酶抑制剂），也用作口服肿瘤治疗药物。
