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[感染后咳嗽——发病机制与治疗选择的现代观点]

[Postinfectious cough - a modern view to the pathogenesis and treatment options].

作者信息

Poniakina M A, Ovchinnikov A Iu, Korostelev S A

出版信息

Vestn Otorinolaringol. 2013(4):78-81.

PMID:24005278
Abstract

The paper presents a literature review regarding the pathogenesis and therapy options of postinfectious (PI) cough.It was shown that the pathogenesis of PI cough may be multifactorial, and in general, the state is of a great interest for otolaryngologists, because on the one hand, there is a large number of patients with PI cough, and on the other hand, it is unclear practical solution. In this regard, since the pharmacological viewpoint of the largest positive effect can be expected with combination of medications with synergistic actions. One of them is Ascoril expectorant whose effectiveness in both children and adults with respect to the dynamics of cough has been demonstrated in many studies.

摘要

本文对感染后(PI)咳嗽的发病机制及治疗选择进行了文献综述。结果表明,PI咳嗽的发病机制可能是多因素的,总体而言,这一情况引起了耳鼻喉科医生的极大兴趣,因为一方面,有大量PI咳嗽患者,另一方面,实际解决方案尚不清楚。在这方面,从药理学角度来看,联合使用具有协同作用的药物有望产生最大的积极效果。其中之一是阿斯美祛痰药,许多研究已证明其在儿童和成人中对咳嗽动态变化的有效性。

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1
[Postinfectious cough - a modern view to the pathogenesis and treatment options].[感染后咳嗽——发病机制与治疗选择的现代观点]
Vestn Otorinolaringol. 2013(4):78-81.
2
There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough.没有充分证据表明常用的非处方药对缓解急性咳嗽有效。
Evid Based Med. 2015 Jun;20(3):98. doi: 10.1136/ebmed-2014-110156. Epub 2015 Mar 5.
3
Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings.用于门诊环境中儿童和成人急性咳嗽的非处方(OTC)药物。
Cochrane Database Syst Rev. 2012 Aug 15(8):CD001831. doi: 10.1002/14651858.CD001831.pub4.
4
Over-the-counter medications for acute cough in children and adults in ambulatory settings.门诊环境中用于儿童和成人急性咳嗽的非处方药。
Cochrane Database Syst Rev. 2008 Jan 23(1):CD001831. doi: 10.1002/14651858.CD001831.pub3.
5
[A pilot phase II study of combination therapy with oxatomide, an antihistamine, plus dextromethoraphan and bakumondo-to, an herbal drug, in patients with postinfectious persistent cough].
Nihon Kokyuki Gakkai Zasshi. 1998 Apr;36(4):338-42.
6
[Effects of oxatomide, H1-antagonist, on postinfectious chronic cough; a comparison of oxatomide combined with dextromethorphan versus dextromethorphan alone].H1拮抗剂奥沙米特对感染后慢性咳嗽的影响;奥沙米特联合右美沙芬与单用右美沙芬的比较
Arerugi. 1998 Jan;47(1):48-53.
7
[On medicinal treatment of cough in chronic bronchitis syndrome].
Ther Ggw. 1968 Apr;107(4):540-5.
8
[General practice-field trials of Linctifed with 17871 patients with inflammatory diseases of the respiratory tract].
Med Welt. 1979 Sep 14;30(37):1374-7.
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Efficacy and safety of Ascoril expectorant and other cough formula in the treatment of cough management in paediatric and adult patients--a randomised double-blind comparative trial.阿斯可立祛痰剂及其他止咳配方在儿童和成人患者咳嗽治疗中的疗效与安全性——一项随机双盲对照试验
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[Statistical study of antitussive synergism in combination of antitussives and expectorants].[镇咳药与祛痰药联合应用的镇咳协同作用的统计学研究]
Nihon Yakurigaku Zasshi. 1969 Sep 20;65(5):446-53.