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The diagnosis of insulitis in human type 1 diabetes.

作者信息

Campbell-Thompson M L, Atkinson M A, Butler A E, Chapman N M, Frisk G, Gianani R, Giepmans B N, von Herrath M G, Hyöty H, Kay T W, Korsgren O, Morgan N G, Powers A C, Pugliese A, Richardson S J, Rowe P A, Tracy S, In't Veld P A

机构信息

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.

出版信息

Diabetologia. 2013 Nov;56(11):2541-3. doi: 10.1007/s00125-013-3043-5. Epub 2013 Sep 5.

DOI:10.1007/s00125-013-3043-5
PMID:24006089
Abstract
摘要

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The diagnosis of insulitis in human type 1 diabetes.人类1型糖尿病中胰岛炎的诊断。
Diabetologia. 2013 Nov;56(11):2541-3. doi: 10.1007/s00125-013-3043-5. Epub 2013 Sep 5.
2
Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats.糖尿病BioBreeding/Worcester大鼠胰岛移植和胰岛中T细胞亚群及I类和II类抗原表达的鉴定
Am J Pathol. 1988 Aug;132(2):292-303.
3
Insulitis in human diabetes: a histological evaluation of donor pancreases.人类糖尿病中的胰岛炎:供体胰腺的组织学评估
Diabetologia. 2017 Feb;60(2):346-353. doi: 10.1007/s00125-016-4140-z. Epub 2016 Oct 28.
4
Congenital rubella, insulitis, and diabetes mellitus in an infant.一名婴儿的先天性风疹、胰岛炎和糖尿病
Lancet. 1981 May 9;1(8228):1048-9. doi: 10.1016/s0140-6736(81)92205-4.
5
[Diagnosis of autoimmune insulitis before the clinical manifestation of type I diabetes mellitus].1型糖尿病临床表现之前自身免疫性胰岛炎的诊断
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6
Insulitis and lymphoid structures in the islets of Langerhans of a 66-year-old patient with long-standing type 1 diabetes.一位患有长期 1 型糖尿病的 66 岁患者胰岛内的胰岛炎和淋巴样结构。
Virchows Arch. 2021 Jun;478(6):1209-1214. doi: 10.1007/s00428-020-02915-4. Epub 2020 Aug 24.
7
[Insulitis in peracute diabetes in children].[儿童急性糖尿病中的胰岛炎]
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Insulitis in type 1 (insulin-dependent) diabetes mellitus in man--macrophages, lymphocytes, and interferon-gamma containing cells.人类1型(胰岛素依赖型)糖尿病中的胰岛炎——巨噬细胞、淋巴细胞及含γ干扰素的细胞
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Role of Fas-FasL in insulitis in nonobese diabetic mouse.Fas-FasL在非肥胖糖尿病小鼠胰岛炎中的作用。
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Early insulitis and the islet vascular system.早期胰岛炎与胰岛血管系统
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引用本文的文献

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Gut-tropic α4β7CD8 T cells contribute to pancreatic β cell destruction in type 1 diabetes.归巢至肠道的α4β7 CD8 T细胞在1型糖尿病中促成胰腺β细胞破坏。
Front Immunol. 2025 Jul 10;16:1623428. doi: 10.3389/fimmu.2025.1623428. eCollection 2025.
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Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression.1型糖尿病进展各阶段人类胰腺的综合组织病理学研究。
Res Sq. 2025 Jun 10:rs.3.rs-6673858. doi: 10.21203/rs.3.rs-6673858/v1.
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3D imaging of human pancreas suggests islet sizeand endocrine composition influence their loss intype 1 diabetes.

本文引用的文献

1
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.糖尿病胰腺器官捐赠者网络(nPOD):建立用于 1 型糖尿病的组织生物库。
Diabetes Metab Res Rev. 2012 Oct;28(7):608-17. doi: 10.1002/dmrr.2316.
2
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.胰岛自身反应性 CD8 T 细胞在近期发病和长期 1 型糖尿病患者胰岛炎病变中的示踪。
J Exp Med. 2012 Jan 16;209(1):51-60. doi: 10.1084/jem.20111187. Epub 2012 Jan 2.
3
Insulitis in human type 1 diabetes: The quest for an elusive lesion.
人类胰腺的3D成像表明,胰岛大小和内分泌组成会影响1型糖尿病中胰岛的丧失。
Res Sq. 2025 Jun 4:rs.3.rs-6759572. doi: 10.21203/rs.3.rs-6759572/v1.
4
Type 1 Diabetes: A Guide to Autoimmune Mechanisms for Clinicians.1型糖尿病:临床医生自身免疫机制指南
Diabetes Obes Metab. 2025 May 15. doi: 10.1111/dom.16460.
5
Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression.1型糖尿病进展各阶段人类胰腺的综合组织病理学研究
bioRxiv. 2025 Mar 19:2025.03.18.644000. doi: 10.1101/2025.03.18.644000.
6
Leveraging pre-trained machine learning models for islet quantification in type 1 diabetes.利用预训练机器学习模型进行1型糖尿病中的胰岛定量分析。
J Pathol Inform. 2024 Nov 8;16:100406. doi: 10.1016/j.jpi.2024.100406. eCollection 2025 Jan.
7
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics.AnnoSpat可从空间蛋白质组学中注释细胞类型并量化细胞排列。
Nat Commun. 2024 May 3;15(1):3744. doi: 10.1038/s41467-024-47334-0.
8
Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature.将 1 型糖尿病的早期病理学重新定位到胰岛外血管。
J Immunol. 2024 Apr 1;212(7):1094-1104. doi: 10.4049/jimmunol.2300769.
9
Canine diabetes mellitus demonstrates multiple markers of chronic inflammation including Th40 cell increases and elevated systemic-immune inflammation index, consistent with autoimmune dysregulation.犬糖尿病表现出多种慢性炎症标志物,包括Th40细胞增加和全身免疫炎症指数升高,这与自身免疫调节异常一致。
Front Immunol. 2024 Jan 22;14:1319947. doi: 10.3389/fimmu.2023.1319947. eCollection 2023.
10
The immunology of type 1 diabetes.1 型糖尿病的免疫学。
Nat Rev Immunol. 2024 Jun;24(6):435-451. doi: 10.1038/s41577-023-00985-4. Epub 2024 Feb 2.
人类 1 型糖尿病中的胰岛炎:追寻难以捉摸的病变。
Islets. 2011 Jul-Aug;3(4):131-8. doi: 10.4161/isl.3.4.15728. Epub 2011 Jul 1.
4
Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study.50 年后糖尿病患者的残余胰岛素生成和胰岛 β 细胞更新:Joslin 奖章研究。
Diabetes. 2010 Nov;59(11):2846-53. doi: 10.2337/db10-0676. Epub 2010 Aug 10.
5
Beta-cell replication is increased in donor organs from young patients after prolonged life support.β细胞在经过长时间生命支持后,来自年轻患者的供体器官中的复制增加。
Diabetes. 2010 Jul;59(7):1702-8. doi: 10.2337/db09-1698. Epub 2010 Apr 22.
6
Dimorphic histopathology of long-standing childhood-onset diabetes.长期儿童起病糖尿病的二态组织病理学。
Diabetologia. 2010 Apr;53(4):690-8. doi: 10.1007/s00125-009-1642-y. Epub 2010 Jan 9.
7
Analysis of islet inflammation in human type 1 diabetes.人类1型糖尿病中胰岛炎症的分析。
Clin Exp Immunol. 2009 Feb;155(2):173-81. doi: 10.1111/j.1365-2249.2008.03860.x.
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Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.患有局部慢性重症胰腺炎的胰腺腺癌患者单个β细胞数量增加,胰岛素分数面积无变化。
Diabetologia. 2009 Feb;52(2):262-70. doi: 10.1007/s00125-008-1200-z. Epub 2008 Nov 11.
9
Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis.死于糖尿病酮症酸中毒的新诊断1型糖尿病患者的β细胞凋亡略有增加,但β细胞复制未增加。
Diabetologia. 2007 Nov;50(11):2323-31. doi: 10.1007/s00125-007-0794-x. Epub 2007 Sep 6.
10
Screening for insulitis in adult autoantibody-positive organ donors.对成年自身抗体阳性器官捐献者进行胰岛炎筛查。
Diabetes. 2007 Sep;56(9):2400-4. doi: 10.2337/db07-0416. Epub 2007 Jun 11.