Wang Li, Yao Min, Dong Zhizhen, Zhang Yun, Yao Dengfu
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
Tumour Biol. 2014 Jan;35(1):9-20. doi: 10.1007/s13277-013-1141-0. Epub 2013 Sep 5.
Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with a multifactorial, multistep, complex process and poor prognosis. Its early diagnosis and metastasis monitoring are of the utmost importance. Hepatoma tissues synthesize various tumor-related proteins, genes, enzymes, microRNA, etc. and then secrete into the blood. Detections of circulating biomarkers are useful to find tumor at an early stage or monitor metastasis after postoperative treatment. This paper summarizes recent studies of specific biomarkers at early diagnosis or in monitoring metastasis or postoperative recurrence of HCC.
肝细胞癌（HCC）是全球最常见且致死率极高的恶性肿瘤之一，其发病过程涉及多因素、多步骤，极为复杂，预后较差。早期诊断和转移监测至关重要。肝癌组织会合成多种肿瘤相关蛋白、基因、酶、微小RNA等，然后分泌到血液中。检测循环生物标志物有助于早期发现肿瘤或监测术后治疗后的转移情况。本文总结了近期关于肝细胞癌早期诊断、转移监测或术后复发的特异性生物标志物的研究。
