Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva (Switzerland).
Chembiochem. 2013 Oct 11;14(15):1927-8. doi: 10.1002/cbic.201300416. Epub 2013 Sep 4.
Just so far apart and no further: Small molecules target ID by DNA tagging. Nucleic acid hybridization has been used to pair a photo-crosslinking group with a small molecule of interest. Following photoactivation, the protein(s) interacting with the small molecule are covalently linked to a nucleic acid tag.
就保持这样的距离，不要更近：小分子通过 DNA 标记来靶向 ID。核酸杂交已被用于将光交联基团与感兴趣的小分子配对。光激活后，与小分子相互作用的蛋白质（s）被共价连接到核酸标记物上。
