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合成生物网络。

Synthetic biological networks.

机构信息

Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

出版信息

Rep Prog Phys. 2013 Sep;76(9):096602. doi: 10.1088/0034-4885/76/9/096602. Epub 2013 Sep 4.

Abstract

Despite their obvious relationship and overlap, the field of physics is blessed with many insightful laws, while such laws are sadly absent in biology. Here we aim to discuss how the rise of a more recent field known as synthetic biology may allow us to more directly test hypotheses regarding the possible design principles of natural biological networks and systems. In particular, this review focuses on synthetic gene regulatory networks engineered to perform specific functions or exhibit particular dynamic behaviors. Advances in synthetic biology may set the stage to uncover the relationship of potential biological principles to those developed in physics.

摘要

尽管物理学领域和生物学领域有着明显的关联和重叠,但物理学领域有许多富有洞察力的定律,而生物学领域却没有这样的定律。在这里,我们旨在讨论一个被称为合成生物学的新兴领域的兴起,如何使我们能够更直接地测试关于自然生物网络和系统可能的设计原则的假设。特别是,本综述侧重于设计用于执行特定功能或表现出特定动态行为的合成基因调控网络。合成生物学的进步可能为揭示潜在生物学原理与物理学中发展的原理之间的关系奠定基础。

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Synthetic gene-regulatory networks in the opportunistic human pathogen .人工合成的基因调控网络在机会性病原体中
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