Tupker R A, Pinnagoda J, Coenraads P J, Nater J P
Department of Dermatology, State University Hospital, Groningen, The Netherlands.
Br J Dermatol. 1990 Aug;123(2):199-205. doi: 10.1111/j.1365-2133.1990.tb01847.x.
The susceptibility of the skin to various irritants was investigated with the aim of determining the role of the barrier function of the stratum corneum, skin dryness and whether a history of atopic dermatitis (AD) was a factor. The transepidermal water loss (TEWL) was measured using an evaporimeter and skin hydration using a Corneometer and by visual scoring. The group with a history of AD (n = 20) had a lower pre-exposure barrier function and a higher TEWL value following irritant exposure than the group with a history of allergic contact dermatitis (n = 18) and a control group (n = 18). Clinically dry skin was more susceptible than normal skin, though no difference was noted in the pre-exposure barrier function. The increased susceptibility to irritants in those with a past history of AD was probably due to impaired barrier function and/or the presence of a dry skin.
为了确定角质层屏障功能、皮肤干燥以及特应性皮炎（AD）病史是否为影响因素，对皮肤对各种刺激物的敏感性进行了研究。使用蒸发仪测量经表皮水分流失（TEWL），并使用角质层水合测量仪和视觉评分法测量皮肤水合作用。有AD病史的组（n = 20）与有过敏性接触性皮炎病史的组（n = 18）和对照组（n = 18）相比，暴露前的屏障功能较低，刺激物暴露后的TEWL值较高。临床上的干性皮肤比正常皮肤更敏感，尽管在暴露前的屏障功能方面未观察到差异。有AD既往史的人对刺激物敏感性增加可能是由于屏障功能受损和/或干性皮肤的存在。
