对于检测肺癌患者的表皮生长因子受体（EGFR）改变，血浆比血清是更好的肿瘤来源循环游离DNA检测样本。 - Suppr

Plasma is a better source of tumor-derived circulating cell-free DNA than serum for the detection of EGFR alterations in lung tumor patients.

作者信息

Vallée Audrey, Marcq Marie, Bizieux Acya, Kouri Claude El, Lacroix Hervé, Bennouna Jaafar, Douillard Jean-Yves, Denis Marc G

机构信息

Department of Biochemistry, Nantes University Hospital, France.

出版信息

Lung Cancer. 2013 Nov;82(2):373-4. doi: 10.1016/j.lungcan.2013.08.014. Epub 2013 Aug 19.

DOI:10.1016/j.lungcan.2013.08.014

PMID:24007628

Abstract

摘要

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Plasma is a better source of tumor-derived circulating cell-free DNA than serum for the detection of EGFR alterations in lung tumor patients.对于检测肺癌患者的表皮生长因子受体（EGFR）改变，血浆比血清是更好的肿瘤来源循环游离DNA检测样本。

Lung Cancer. 2013 Nov;82(2):373-4. doi: 10.1016/j.lungcan.2013.08.014. Epub 2013 Aug 19.

Detection and comparison of EGFR mutations in matched tumor tissues, cell blocks, pleural effusions, and sera from patients with NSCLC with malignant pleural effusion, by PNA clamping and direct sequencing.采用 PNA 钳夹和直接测序法检测并比较伴有恶性胸腔积液的 NSCLC 患者的配对肿瘤组织、细胞块、胸腔积液和血清中的 EGFR 突变。

Lung Cancer. 2013 Aug;81(2):207-12. doi: 10.1016/j.lungcan.2013.04.023. Epub 2013 May 29.

Detection of EGFR mutation status in lung adenocarcinoma specimens with different proportions of tumor cells using two methods of differential sensitivity.采用两种差异敏感性方法检测不同肿瘤细胞比例肺腺癌标本中的 EGFR 突变状态。

J Thorac Oncol. 2012 Feb;7(2):355-64. doi: 10.1097/JTO.0b013e31823c4c1b.

Predicting outcomes of EGFR-targeted therapy in non-small cell lung cancer patients using pleural effusions samples and peptide nucleic acid probe assay.利用胸腔积液样本和肽核酸探针检测法预测非小细胞肺癌患者表皮生长因子受体靶向治疗的疗效

Clin Chem Lab Med. 2017 Oct 26;55(12):1979-1986. doi: 10.1515/cclm-2016-0809.

A primer and probe set for detecting multiple types of EGFR exon 19 deletions.一种用于检测多种类型表皮生长因子受体（EGFR）第19外显子缺失的引物和探针组。

Anal Biochem. 2016 Nov 15;513:61-67. doi: 10.1016/j.ab.2016.09.002. Epub 2016 Sep 4.

Assessment of real-time PCR method for detection of EGFR mutation using both supernatant and cell pellet of malignant pleural effusion samples from non-small-cell lung cancer patients.使用非小细胞肺癌患者恶性胸腔积液样本的上清液和细胞沉淀检测EGFR突变的实时PCR方法的评估。

Clin Chem Lab Med. 2017 Oct 26;55(12):1962-1969. doi: 10.1515/cclm-2016-0851.

EGFR mutation status in tumour-derived DNA from pleural effusion fluid is a practical basis for predicting the response to gefitinib.来自胸腔积液的肿瘤源性DNA中的表皮生长因子受体（EGFR）突变状态是预测吉非替尼疗效的实际依据。

Br J Cancer. 2006 Nov 20;95(10):1390-5. doi: 10.1038/sj.bjc.6603428. Epub 2006 Oct 24.

Detection and comparison of epidermal growth factor receptor mutations in cells and fluid of malignant pleural effusion in non-small cell lung cancer.非小细胞肺癌恶性胸腔积液细胞及积液中表皮生长因子受体突变的检测与比较

Lung Cancer. 2008 May;60(2):175-82. doi: 10.1016/j.lungcan.2007.10.011. Epub 2007 Dec 3.

EGFR mutations in malignant pleural effusion of non-small cell lung cancer: a case report.非小细胞肺癌恶性胸腔积液中的表皮生长因子受体突变：一例报告

Lung Cancer. 2005 Sep;49(3):413-5. doi: 10.1016/j.lungcan.2005.02.016.

Improved detection of EGFR mutations in the tumor cells enriched from the malignant pleural effusion of non-small cell lung cancer patient.非小细胞肺癌患者恶性胸腔积液中富集的肿瘤细胞中表皮生长因子受体（EGFR）突变检测的改进

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Plasma is a better source of tumor-derived circulating cell-free DNA than serum for the detection of EGFR alterations in lung tumor patients.

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