人类嗜T淋巴细胞病毒1型（HTLV-1）与白血病发生：成人T细胞白血病发展过程中的病毒-细胞相互作用
HTLV-1 and leukemogenesis: virus-cell interactions in the development of adult T-cell leukemia.
作者信息
Zane Linda, Jeang Kuan-Teh
机构信息
Molecular Virology Section, Laboratory of Molecular Microbiology, The National Institutes of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD, 20892-0460, USA.
出版信息
Recent Results Cancer Res. 2014;193:191-210. doi: 10.1007/978-3-642-38965-8_11.
Human T-cell lymphotropic virus type 1 (HTLV-1) was originally discovered in the early 1980s. It is the first retrovirus to be unambiguously linked causally to a human cancer. HTLV-1 currently infects approximately 20 million people worldwide. In this chapter, we review progress made over the last 30 years in our understanding of HTLV-1 infection, replication, gene expression, and cellular transformation.
人类嗜T淋巴细胞病毒1型（HTLV-1）最初于20世纪80年代初被发现。它是第一种被明确证实与人类癌症有因果关系的逆转录病毒。目前，HTLV-1在全球感染了约2000万人。在本章中，我们回顾了过去30年来我们对HTLV-1感染、复制、基因表达和细胞转化的认识所取得的进展。
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