25岁时的人类嗜T淋巴细胞病毒I型：进展报告。
Human T-cell leukemia virus type I at age 25: a progress report.
作者信息
Matsuoka Masao, Jeang Kuan-Teh
机构信息
Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan.
出版信息
Cancer Res. 2005 Jun 1;65(11):4467-70. doi: 10.1158/0008-5472.CAN-05-0559.
It has been 25 years since the discovery of human T-cell leukemia virus type I (HTLV-I) and its role in adult T-cell leukemia. Here, in brief, we review the current state of our understanding of HTLV-I epidemiology, viral biology, pathogenesis, and treatment. We discuss how HTLV-I may transform cells through destabilization of cellular genomic integrity and induction of cellular tolerance for chromosomal errors.
自发现人类T细胞白血病病毒I型（HTLV-I）及其在成人T细胞白血病中的作用以来，已经过去了25年。在此，我们简要回顾一下目前我们对HTLV-I流行病学、病毒生物学、发病机制和治疗的理解现状。我们讨论了HTLV-I如何通过破坏细胞基因组完整性和诱导细胞对染色体错误的耐受性来转化细胞。
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