Qi Qibin, Xu Min, Wu Hongyu, Liang Liming, Champagne Catherine M, Bray George A, Sacks Frank M, Qi Lu
Corresponding author: Lu Qi,
Diabetes Care. 2013 Nov;36(11):3442-7. doi: 10.2337/dc13-0018. Epub 2013 Sep 5.
Genetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS status in a 2-year weight-loss trial.
Two variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 ± 9 years; BMI 32.7 ± 3.9 kg/m2) randomly assigned to one of four weight-loss diets (a deficit of 750 kcal/day of caloric intake from baseline) varying in macronutrient contents for 2 years. We compared MetS status of high-fat (40% of caloric intake; n = 370) and low-fat (20% caloric intake; n = 368) diet groups differentiated by genotypes (rs1522813 A-allele carriers and noncarriers and rs2943641T-allele carriers and noncarriers).
Among rs1522813 A-allele carriers, the reversion rates of the MetS were higher in the high-fat diet group than those in the low-fat diet group over the 2-year intervention (P = 0.002), while no significant difference between diet groups was observed among noncarriers (P = 0.27). The genetic modulation on dietary effect was independent of weight changes. The odds ratio (OR) for the 2-year reversion of the MetS was 2.88 (95% CI 1.25-6.67) comparing the high-fat and low-fat diets among rs1522813 A-allele carriers, while the corresponding OR was 0.83 (0.36-1.92) in noncarriers. The variant rs2943641 was not observed to modulate dietary effects on the MetS status.
Our data suggest that high-fat weight-loss diets might be more effective in the management of the MetS compared with low-fat diets among individuals with the A-allele of the rs1522813 variant near IRS1.
胰岛素受体底物1（IRS1）附近的基因变异与代谢综合征（MetS）的特征相关。在一项为期两年的减肥试验中，我们研究了IRS1附近的基因变异是否可能调节不同脂肪含量饮食对MetS状态的影响。
对738名超重/肥胖成年人（年龄60±9岁；体重指数32.7±3.9kg/m²）进行IRS1附近的两个变异rs1522813和rs2943641的基因分型，这些成年人被随机分配到四种减肥饮食之一（热量摄入比基线减少750千卡/天），这四种饮食的宏量营养素含量不同，为期两年。我们比较了按基因型（rs1522813 A等位基因携带者和非携带者以及rs2943641 T等位基因携带者和非携带者）区分的高脂肪（热量摄入的40%；n = 370）和低脂肪（热量摄入的20%；n = 368）饮食组的MetS状态。
在rs1522813 A等位基因携带者中，在为期两年的干预期间，高脂肪饮食组的MetS逆转率高于低脂肪饮食组（P = 0.002），而在非携带者中，饮食组之间未观察到显著差异（P = 0.27）。基因对饮食效果的调节与体重变化无关。在rs1522813 A等位基因携带者中，比较高脂肪和低脂肪饮食时，MetS两年逆转的优势比（OR）为2.88（95%可信区间1.25 - 6.67），而在非携带者中相应的OR为0.83（0.36 - 1.92）。未观察到变异rs2943641调节饮食对MetS状态的影响。
我们的数据表明，在IRS1附近rs1522813变异的A等位基因个体中，与低脂肪饮食相比，高脂肪减肥饮食在管理MetS方面可能更有效。
