Hilton D A, West K P
Department of Histopathology, Leicester Royal Infirmary, United Kingdom.
Cancer. 1990 Sep 15;66(6):1154-7. doi: 10.1002/1097-0142(19900915)66:6<1154::aid-cncr2820660613>3.0.co;2-3.
The prognostic value of histochemical staining for HLA-DR was assessed retrospectively in 52 "curative" gastrectomy specimens from patients with gastric carcinoma. In addition other tumor variables, including histologic type, degree of differentiation, extent of local spread, prominence of mononuclear infiltrate, tumor edge, and lymph-node metastases, were examined. Sixty-five percent of the tumors showed positive staining for HLA-DR, and these tumors had a higher mean and median survival at 5 years compared with negative tumors. However, on multivariate analysis the difference was not statistically significant. The authors conclude that, although HLA-DR staining is associated with tumors of better prognosis, it cannot be used as an independent prognostic factor. Of the other tumor variables, only lymph-node status was of prognostic significance.
对52例接受“根治性”胃切除术的胃癌患者标本进行回顾性评估，以研究HLA - DR组织化学染色的预后价值。此外，还检查了其他肿瘤变量，包括组织学类型、分化程度、局部扩散范围、单核细胞浸润程度、肿瘤边缘和淋巴结转移情况。65%的肿瘤HLA - DR染色呈阳性，与阴性肿瘤相比，这些肿瘤5年的平均和中位生存期更高。然而，多变量分析显示差异无统计学意义。作者得出结论，虽然HLA - DR染色与预后较好的肿瘤相关，但它不能作为独立的预后因素。在其他肿瘤变量中，只有淋巴结状态具有预后意义。
