Ogoshi K, Tajima T, Mitomi T, Tsuji K
Department of Surgery, Tokai University, School of Medicine, Kanagawa, Japan.
Clin Exp Metastasis. 1996 May;14(3):277-81. doi: 10.1007/BF00053901.
We investigated the association between human leucocyte antigen (HLA) antigens and lymph node metastasis in 724 gastric cancer patients. Among patients who had poorly differentiated adenocarcinoma with or without HLA-DR4 antigen, lymph node metastasis was detected in 80.8 and 54.9%, respectively (relative risk (RR) = 3.5, P = 0.0005, corrected P = 0.0285). It was more common in patients with a family history of cancer death (RR = 7.7). Among signet ring cell carcinoma patients with or without HLA-B52 antigen, lymph node metastasis was detected in 57.7 and 19.7%, respectively (RR = 5.6, P = 0.0001, corrected P = 0.0086). It was more common in patients who were smokers (RR= 8.3). Our findings suggest that HLA-DR4 and HLA-B52 antigens are associated with lymph node metastasis in gastric cancer.
我们调查了724例胃癌患者中人类白细胞抗原（HLA）与淋巴结转移之间的关联。在患有或不患有HLA-DR4抗原的低分化腺癌患者中，淋巴结转移率分别为80.8%和54.9%（相对风险（RR）= 3.5，P = 0.0005，校正P = 0.0285）。在有癌症死亡家族史的患者中更常见（RR = 7.7）。在患有或不患有HLA-B52抗原的印戒细胞癌患者中，淋巴结转移率分别为57.7%和19.7%（RR = 5.6，P = 0.0001，校正P = 0.0086）。在吸烟者中更常见（RR = 8.3）。我们的研究结果表明，HLA-DR4和HLA-B52抗原与胃癌淋巴结转移有关。
