神经化学证据表明存在黑质-顶盖 GABAergic 投射。
Neurochemical evidence for a nigrotegmental GAbAergic projection.
机构信息
Department of Pharmacology, Schools of Medicine and Dentistry, Georgetown University, Washington, DC 20007, USA.
出版信息
Brain Res. 1983 Jan 3;258(1):109-14. doi: 10.1016/0006-8993(83)91233-7.
Axonal transport of [3H]GABA from substantia nigra to the pontomesencephalic tegmentum was demonstrated in rats pretreated with the GABA-transaminase inhibitor, gamma-vinyl-GABA. In addition, kainic acid lesions of substantia nigra resulted in a significant loss of glutamic acid decarboxylase activity in the vicinity of the ipsilateral pedunculopontine nucleus and in adjacent tissue of the pontomesencephalic tegmentum. These data support the thesis that the nigrotegmental projection is both diffuse and GABAergic.
经γ-乙烯基-GABA（一种 GABA 转氨酶抑制剂）预处理的大鼠中，观察到[3H]GABA 从黑质向脑桥中脑被盖的轴突运输。此外，黑质内的红藻氨酸损伤导致同侧脚桥被盖核及其邻近的脑桥中脑被盖组织中谷氨酸脱羧酶活性显著丧失。这些数据支持黑质投射既弥散又 GABA 能的假说。
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