电损毁中隔腹内侧区对大鼠基础及渴觉性血管加压素分泌的影响。

Basal and thirst-evoked vasopressin secretion in rats with electrolytic lesion of the medio-ventral septal area.

机构信息

Laboratory of Neuroendocrinology, UER Biomedical, René Descartes University, 45, rue des Saints-Pares, 750270 Paris Cedex 06, France.

出版信息

Brain Res. 1983 Jan 3;258(1):123-6. doi: 10.1016/0006-8993(83)91236-2.

DOI:10.1016/0006-8993(83)91236-2

PMID:24010174

Abstract

Electrolytic lesion of the medio-ventral septal (MVS) area produces, 3 days after the surgery, a remarkable increase of daily diuresis and water intake in the rat. This polyuria and polydipsia is associated with decreased levels of circulating radioimmunoassayable vasopressin. In addition, if these lesioned animals were water-deprived (48 h), the usual vasopressin release observed in sham-lesioned and normal controls was markedly blunted. These results suggest that the MVS area exerts a modulatory control on vasopressin secretion both in basal and thirst-evoked conditions.

摘要

电损毁中隔腹内侧（MVS）区后，大鼠在术后第 3 天出现明显的日尿量和饮水量增加。这种多尿和多饮与循环中放射免疫可测血管加压素水平降低有关。此外，如果这些损伤动物被剥夺水（48 小时），则在假损伤和正常对照中观察到的通常的血管加压素释放明显减弱。这些结果表明，MVS 区对基础和口渴诱发条件下的血管加压素分泌具有调节控制作用。