Department of Pharmacology, Emory University, Atlanta, GA 30322, USA.
Brain Res. 1983 Jan 3;258(1):147-51. doi: 10.1016/0006-8993(83)91241-6.
The effects of microiontophoretically administered dibutyryl cyclic GMP (dbcGMP), morphine and Met-enkephalin on neuronal firing in the mesencephalic reticular formation of the rat were examined. DbcGMP did not mimic the ability of either opioid to block neuronal firing evoked by a nociceptive stimulus. Furthermore, dbcGMP did not potentiate the ability of the opioid to block evoked neuronal firing. The only effect of dbcGMP was an occasional enhancement of both evoked and spontaneous neuronal firing. These data may indicate that the effects of morphine and Met-enkephalin in the mesencephalic reticular formation of the rat are not linked to cyclic GMP.
观察了微电泳给予的二丁基环鸟苷（dbcGMP）、吗啡和 Met-脑啡肽对大鼠中脑网状结构神经元放电的影响。dbcGMP 不能模拟任何一种阿片类药物阻断伤害性刺激引起的神经元放电的能力。此外，dbcGMP 也不能增强阿片类药物阻断诱发放电的能力。dbcGMP 的唯一作用是偶尔增强诱发放电和自发放电。这些数据可能表明，吗啡和 Met-脑啡肽在大鼠中脑网状结构中的作用与环鸟苷无关。
