Pancotto T E, Rossmeisl J H, Zimmerman K, Robertson J L, Werre S R
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA.
J Vet Intern Med. 2013 Nov-Dec;27(6):1500-8. doi: 10.1111/jvim.12182. Epub 2013 Sep 6.
Intramedullary neoplasms of the canine spinal cord are infrequently reported.
To describe distribution, clinicopathologic characteristics, radiographic findings, and clinical features of canine intramedullary spinal tumors.
Retrospective series of histologically confirmed canine intramedullary spinal tumors. Contingency tables were generated for categorical variables (breed, sex, treatment, pain, chief complaint, localization, histology, imaging, and site). Associations were assessed by Fisher's exact, Wilcoxon rank sum test, t-test, and one-way ANOVA.
Intramedullary spinal cord tumors comprised 16% (53/331) of all tumors of the spinal cord. Primary tumors were diagnosed in 66% (35/53) of cases, with neuroepithelial-origin tumors comprising 51% (18/35) of all primary neoplasms. Intraparenchymal metastases of transitional cell carcinoma and hemangiosarcoma accounted for 66% (6/18 each) of all secondary tumors. Primary tumors were more likely to affect younger dogs. Dogs with intramedullary metastases were most commonly presented for primary myelopathic signs (8/18, 44%). The majority of all tumors (52.8%) occurred in the T3-L3 spinal cord segments. All dogs with cervical neurolocalization had primary tumors. Dogs with metastatic lesions had a shorter duration of clinical signs before presentation, but there was no difference in survival time between dogs with primary as compared with secondary tumors.
Intramedullary spinal cord tumors are uncommon. Primary intramedullary spinal cord tumors are more common than secondary intramedullary spinal cord tumors and tend to occur in the cervical spinal cord of younger dogs. Intramedullary metastases occur in older dogs, are rarely asymptomatic, and neurologic dysfunction is a common clinical presentation. Dogs with primary tumors may have a protracted clinical course compared with those with intramedullary metastases.
犬脊髓髓内肿瘤的报道较少。
描述犬脊髓髓内肿瘤的分布、临床病理特征、影像学表现及临床特点。
对组织学确诊的犬脊髓髓内肿瘤进行回顾性研究。针对分类变量（品种、性别、治疗、疼痛、主要诉求、定位、组织学、影像学及部位）生成列联表。采用Fisher精确检验、Wilcoxon秩和检验、t检验及单因素方差分析评估相关性。
脊髓髓内肿瘤占所有脊髓肿瘤的16%（53/331）。66%（35/53）的病例诊断为原发性肿瘤，其中神经上皮起源的肿瘤占所有原发性肿瘤的51%（18/35）。移行细胞癌和血管肉瘤的实质内转移分别占所有继发性肿瘤的66%（各6/18）。原发性肿瘤更易影响年轻犬。脊髓髓内转移的犬最常见的表现为原发性脊髓病体征（8/18，44%）。所有肿瘤的大多数（52.8%）发生在T3 - L3脊髓节段。所有具有颈部神经定位的犬均患有原发性肿瘤。有转移灶的犬在出现临床症状前的持续时间较短，但原发性肿瘤犬与继发性肿瘤犬的生存时间无差异。
脊髓髓内肿瘤并不常见。原发性脊髓髓内肿瘤比继发性脊髓髓内肿瘤更常见，且倾向于发生在年轻犬的颈髓。脊髓髓内转移发生在老年犬，很少无症状，神经功能障碍是常见的临床表现。与脊髓髓内转移的犬相比，原发性肿瘤的犬可能有较长的临床病程。
