Donnet M L, Howie P W, Marnie M, Cooper W, Lewis M
Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee, UK.
Clin Endocrinol (Oxf). 1990 Jul;33(1):13-20. doi: 10.1111/j.1365-2265.1990.tb00460.x.
Assays of first morning urine samples for oestrone-3-glucuronide, LH and pregnanediol-3-glucuronide, were used to study endocrine function and return to ovulation in 18 subjects following spontaneous miscarriage. On the basis of the endocrine data, ovulation occurred in all 18 women in the cycle prior to first menses at a mean of 29 days post-partum (range 13-103 days) with one subject conceiving in that cycle. Compared with the second cycle, the first cycle after spontaneous abortion had similar levels of follicular phase peak ovulatory oestrone excretion but lower levels during the late luteal phase (P less than 0.02), lower levels of peak LH (50.5 IU/g creatinine (C) cf. 68.8 IU/g C; P less than 0.04) and lower late secretory peak pregnanediol (4.6 mg/g C cf. 6.1 mg/g C; P less than 0.02). The mean luteal phase length of 12.9 days in the first cycle was shorter than the mean of 14.4 days in the second cycle (P less than 0.02). These data show that, although there is some disturbance of endocrine function in the first cycle after spontaneous abortion, the majority of women have a rapid return to ovulation, making the early use of contraception necessary for those wishing to avoid conception.
对18名自然流产后的受试者，检测其晨尿样本中的雌酮-3-葡萄糖醛酸苷、促黄体生成素（LH）和孕二醇-3-葡萄糖醛酸苷，以研究内分泌功能及排卵恢复情况。根据内分泌数据，所有18名女性在产后平均29天（范围13 - 103天）的第一个月经周期前的周期中排卵，其中一名受试者在此周期受孕。与第二个周期相比，自然流产后的第一个周期卵泡期峰值排卵雌酮排泄水平相似，但黄体晚期水平较低（P<0.02），LH峰值水平较低（50.5 IU/g肌酐（C）对比68.8 IU/g C；P<0.04），分泌晚期峰值孕二醇水平较低（4.6 mg/g C对比6.1 mg/g C；P<0.02）。第一个周期的平均黄体期长度为12.9天，短于第二个周期的平均14.4天（P<0.02）。这些数据表明，虽然自然流产后的第一个周期内分泌功能有一些紊乱，但大多数女性排卵迅速恢复，这使得希望避免受孕的女性有必要尽早使用避孕措施。
