Kincaid-Smith P, Macdonald I M, Hua A, Laver M C, Fang P
Med J Aust. 1975 Mar 15;1(11):327-32. doi: 10.5694/j.1326-5377.1975.tb111421.x.
Experience in a hypertension clinic attended by 591 patients over a 13-year period has shown marked changes in the pattern of use of hypotensive agents. Thiazides have been used throughout the period in almost all cases. Methyldopa was used for most patients for almost a decade. Since 1967 there has been a steady increase in the use of beta adrenergic blocking agents, and these are now used for over 60% of patients attending the clinic. Combination beta adrenergic blocking agents with peripheral vasilodators such as hydrallazine and prazosin have provided a very effective means of controlling the blood pressure in moderate and severe hypertension. Prazosin, a new peripheral vasodilator, has been used in the treatment of 295 patients. In most cases it has been used in combination with a thiazide diuretic and beta adrenergic blocking agent. Open studies have demonstrated that this is an effective hypot .ensive agent. Side effects are few and are counteracted by combination with a beta adrenergic blocking agent. Prazosin and hydrallazine are being compared in double-blind studies.
在一家高血压诊所13年期间接诊591名患者的经验显示，降压药的使用模式发生了显著变化。在此期间，几乎所有病例都使用了噻嗪类药物。甲基多巴在近十年内被大多数患者使用。自1967年以来，β肾上腺素能阻滞剂的使用稳步增加，目前该诊所超过60%的患者使用此类药物。β肾上腺素能阻滞剂与外周血管扩张剂如肼屈嗪和哌唑嗪联合使用，为控制中度和重度高血压提供了一种非常有效的方法。新型外周血管扩张剂哌唑嗪已用于治疗295名患者。在大多数情况下，它与噻嗪类利尿剂和β肾上腺素能阻滞剂联合使用。开放研究表明，这是一种有效的降压药。副作用很少，与β肾上腺素能阻滞剂联合使用可抵消副作用。正在进行双盲研究比较哌唑嗪和肼屈嗪。
