Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, 500046, India; Institute of Biological Sciences, University of Malaya, Kuala Lumpur, 50603, Malaysia.
Helicobacter. 2013 Sep;18 Suppl 1:1-4. doi: 10.1111/hel.12069.
We describe features of key additions to the existing pool of publicly accessible Helicobacter pylori genome sequences and sequences of Helicobacter pylori phages from April 2012 to March 2013. In addition, important studies involving H. pylori genomes, especially those pertaining to genomic diversity, disease outcome, H. pylori population structure and evolution are reviewed. High degree of homologous recombination contributes to increased diversity of H. pylori genomes. New methods of resolving H. pylori population structure to an ultrafine level led to the proposal of new subpopulations. As the magnitude of diversity in the H. pylori gene pool becomes more and more clear, geographic and demographic factors should be brought to analysis while identifying disease-specific biomarkers and defining new virulence mechanisms.
我们描述了 2012 年 4 月至 2013 年 3 月期间，现有公开可获取的幽门螺杆菌基因组序列和幽门螺杆菌噬菌体序列中新增内容的特点。此外，还回顾了涉及幽门螺杆菌基因组的重要研究，特别是与基因组多样性、疾病结果、幽门螺杆菌种群结构和进化相关的研究。高度同源重组有助于增加幽门螺杆菌基因组的多样性。新的方法可将幽门螺杆菌种群结构解析到超精细水平，从而提出了新的亚群。随着幽门螺杆菌基因库中多样性的程度变得越来越清晰，在确定特定疾病的生物标志物和定义新的毒力机制时，应该引入地理和人口统计学因素进行分析。
