Chu J X
Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin.
Zhonghua Zhong Liu Za Zhi. 1990 Mar;12(2):98-100.
Using patho-morphological method and transplantation bio-assay, the in vivo invasiveness of leukemia cells in three transplantable mouse T cell leukemia models was comparatively studied. The results showed that the invasion to the liver was consistent, but that to other organs was obviously different. L615 and L7212 leukemia cells preferred bone marrow and spleen to peritoneum but L7811 leukemia cells were just the opposite. Transplantation bio-assay demonstrated that leukemia cells were present in the bone marrow of L615 mice as early as 6 hours after leukemic cell inoculation, but no leukemia cells were detected in the bone marrow of L7811 mice 2 days after inoculation. In the terminal phase, L615 mice bone marrow became filled with leukemia cells, but L7811 mice bone marrow contained only a few leukemia cells. The difference in invasiveness of leukemia cells into organs is probably related to "homing" receptor. The same type of leukemia cells may possess multiple "homing" receptors.
采用病理形态学方法和移植生物测定法，对三种可移植性小鼠T细胞白血病模型中白血病细胞的体内侵袭性进行了比较研究。结果表明，白血病细胞对肝脏的侵袭情况一致，但对其他器官的侵袭情况明显不同。L615和L7212白血病细胞更倾向于侵袭骨髓和脾脏而非腹膜，而L7811白血病细胞则相反。移植生物测定显示，L615小鼠在接种白血病细胞后6小时骨髓中就出现了白血病细胞，但L7811小鼠在接种2天后骨髓中未检测到白血病细胞。在终末期，L615小鼠骨髓中充满了白血病细胞，而L7811小鼠骨髓中仅含有少量白血病细胞。白血病细胞对器官侵袭性的差异可能与“归巢”受体有关。同一类型的白血病细胞可能具有多种“归巢”受体。
