Traumatic Stress Studies Division, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
Endocrinol Metab Clin North Am. 2013 Sep;42(3):503-13. doi: 10.1016/j.ecl.2013.05.004.
Post-traumatic stress disorder (PTSD) is a serious, multisystem disorder with multiple medical comorbidities. This article reviews the current literature on the endocrine aspects of PTSD, specifically hypothalamic-pituitary-adrenal axis alterations indicative of low cortisol and increased glucocorticoid sensitivity, and the proposed mechanisms whereby these alterations increase risk or reflect pathophysiology. Discussion includes novel treatment innovations and directions for future research.
创伤后应激障碍（PTSD）是一种严重的多系统障碍，伴有多种医学合并症。本文综述了 PTSD 内分泌方面的现有文献，特别是提示皮质醇降低和糖皮质激素敏感性增加的下丘脑-垂体-肾上腺轴改变，以及这些改变增加风险或反映病理生理学的可能机制。讨论包括新的治疗创新和未来研究方向。
