Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea.
Department of Psychiatry, Gachon University Gil Medical Center, 1198, Guwol-dong, Namdong-Gu, Incheon, Republic of Korea.
J Affect Disord. 2013 Nov;151(2):738-743. doi: 10.1016/j.jad.2013.07.041. Epub 2013 Aug 22.
Neurotrophic factors exert substantial effects on the central nervous system. The present study investigates the roles of insulin-like growth factor-1 (IGF-1), β-nerve growth factor (β-NGF), and brain-derived neurotrophic factor (BDNF) in bipolar disorder.
Baseline levels of culture-stimulated IGF-1, β-NGF, and BDNF were compared in 116 patients with bipolar I disorder and 123 healthy controls. Neurotrophic factors were also compared in patients before and after 6 weeks of pharmacotherapy. A multivariate logistic regression analysis was used to investigate the influence of the neurotrophic factors analyzed in quartile form, in relation to confounding variables, such as age, sex, and body mass index.
IGF-1 was significantly higher in patients (mean=514.57, SD=259.78) than in healthy controls (mean=316.82, SD=270.00, p<0.0001) at baseline. Furthermore, higher levels of IGF-1 substantially increased the risk for bipolar I disorder. IGF-1 level was not significantly changed at 6-weeks (mean=506.41, SD=313.66). No changes in BDNF or β-NGF-1 levels were found following the 6-week treatment period. IGF-1 and β-NGF were negatively correlated in healthy controls, but not in patients. Severity of manic symptoms was not associated with any of the neurotrophic factors.
We did not measure cortisol, growth hormone, or IGF-1 receptors. This study is cross-sectional in design.
Elevated IGF-1 levels may be a trait marker for bipolar disorder. Further studies are needed to thoroughly investigate the role of IGF-1 in relation to other neuroendocrine factors and biological markers for bipolar disorder.
神经营养因子对中枢神经系统有显著影响。本研究调查胰岛素样生长因子-1（IGF-1）、β-神经生长因子（β-NGF）和脑源性神经营养因子（BDNF）在双相情感障碍中的作用。
比较 116 例双相 I 型障碍患者和 123 例健康对照者在基线时培养刺激的 IGF-1、β-NGF 和 BDNF 的水平。还比较了患者在 6 周药物治疗前后的神经营养因子。使用多元逻辑回归分析，以调查在四分位形式分析的神经营养因子的影响，与年龄、性别和体重指数等混杂变量有关。
IGF-1 在患者（平均=514.57，SD=259.78）中的水平明显高于健康对照组（平均=316.82，SD=270.00，p<0.0001）。此外，较高的 IGF-1 水平大大增加了双相 I 型障碍的风险。IGF-1 水平在 6 周时没有明显变化（平均=506.41，SD=313.66）。在 6 周治疗期间，BDNF 或 β-NGF-1 水平没有变化。IGF-1 和 β-NGF 在健康对照组中呈负相关，但在患者中则不然。躁狂症状的严重程度与任何一种神经营养因子均无关。
我们没有测量皮质醇、生长激素或 IGF-1 受体。本研究为横断面设计。
升高的 IGF-1 水平可能是双相情感障碍的特征性标志物。需要进一步研究以彻底调查 IGF-1 与其他神经内分泌因素和双相情感障碍的生物标志物的关系。
