Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China.
Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China.
Psychiatry Res. 2014 Aug 15;218(1-2):54-60. doi: 10.1016/j.psychres.2014.03.042. Epub 2014 Apr 8.
Multiple neurotrophic and/or growth factors, recently nominated as "angioneurins", play the key roles in mood modulation and neuroplasticity, and their dysfunction might be involved in the pathophysiology and treatment of mood disorders. We examined serum levels of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)-2, nerve growth factor (NGF) and insulin-like growth factor (IGF)-1 in 70 drug-naïve or drug-free patients with manic episode of bipolar disorder and 50 healthy controls, using the enzyme-linked immunosorbent assay (ELISA) method. The results showed that mean serum levels of VEGF, FGF-2, NGF and IGF-1 were 168.13±225.61pg/ml, 279.09±378.62pg/ml, 61.38±171.67pg/ml and 162.01±72.00ng/ml in patients, and 140.80±143.71pg/ml, 275.46±235.29pg/ml, 36.34±15.14pg/ml and 138.90±80.11ng/ml in healthy controls, respectively. Serum levels of FGF-2, NGF and IGF-1 in patients were significantly higher than those in healthy controls, though there was no statistical difference in serum VEGF level between two groups. Moreover, serum NGF level in patients was significantly correlated with duration of disorder and times of previous manic episodes. We conclude that the increase of serum FGF-2, NGF and IGF-1 levels in manic state of bipolar disorder may be associated with their compensatory roles of neuroprotection and angiogenesis, and these angioneurins may be involved in the pathophysiology of bipolar disorder.
多种神经营养因子和/或生长因子，最近被命名为“血管神经生成因子”，在情绪调节和神经可塑性中发挥关键作用，其功能障碍可能与心境障碍的病理生理学和治疗有关。我们采用酶联免疫吸附试验（ELISA）方法检测了 70 例未经药物治疗或药物治疗的双相情感障碍躁狂发作患者和 50 例健康对照者的血清血管内皮生长因子（VEGF）、成纤维细胞生长因子（FGF）-2、神经生长因子（NGF）和胰岛素样生长因子（IGF）-1 水平。结果显示，患者血清 VEGF、FGF-2、NGF 和 IGF-1 水平分别为 168.13±225.61pg/ml、279.09±378.62pg/ml、61.38±171.67pg/ml 和 162.01±72.00ng/ml，健康对照者分别为 140.80±143.71pg/ml、275.46±235.29pg/ml、36.34±15.14pg/ml 和 138.90±80.11ng/ml。与健康对照组相比，患者血清 FGF-2、NGF 和 IGF-1 水平明显升高，而两组血清 VEGF 水平无统计学差异。此外，患者血清 NGF 水平与疾病持续时间和既往躁狂发作次数显著相关。我们的结论是，双相情感障碍躁狂状态下血清 FGF-2、NGF 和 IGF-1 水平的升高可能与其神经保护和血管生成的代偿作用有关，这些血管神经生成因子可能与双相情感障碍的病理生理学有关。
