Department of Cell Biology, Second Military Medical University, Shanghai 200433, China.
Cell Stem Cell. 2013 Sep 5;13(3):270-83. doi: 10.1016/j.stem.2013.08.002.
Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and have facilitated the development of cell-based therapies and therapeutic drugs targeting endogenous stem and progenitor cells for repair and regeneration. Here, we will discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine.
小分子调节干细胞命运和功能提供了重大的机会,将允许充分实现干细胞的治疗潜力。小分子的合理设计和筛选已经确定了有用的化合物来探索干细胞自我更新、分化和重编程的基本机制,并促进了基于细胞的治疗方法和针对内源性干细胞和祖细胞的治疗药物的发展,以进行修复和再生。在这里,我们将讨论最近在干细胞生物学和再生医学中使用化学方法的科学和治疗进展,以及新的观点和未来的挑战。