小分子在细胞重编程和心脏修复中的应用：进展与展望。
Small molecules for cell reprogramming and heart repair: progress and perspective.
机构信息
The Gladstone Institutes, 1650 Owens Street, San Francisco, California 94158, United States.
出版信息
ACS Chem Biol. 2014 Jan 17;9(1):34-44. doi: 10.1021/cb400865w. Epub 2014 Jan 6.
Abstract
Regenerative medicine for heart failure seeks to replace lost cardiomyocytes. Chemical approaches for producing ample supplies of cells, such as pluripotent stem cells and cardiomyocytes, hold promise as practical means to achieve safe, facile cell-based therapy for cardiac repair and regenerative medicine. In this review, we describe recent advances in the application of small molecules to improve the generation and maintenance of pluripotent stem cells. We also describe new directions in heart repair and regeneration in which chemical approaches may find their application.
摘要
再生医学旨在治疗心力衰竭，通过替换失去的心肌细胞来实现。化学方法，如多能干细胞和心肌细胞，可以产生大量的细胞，为安全、简便的基于细胞的心脏修复和再生医学治疗提供了实用手段。在这篇综述中，我们描述了小分子在改善多能干细胞的生成和维持方面的最新进展。我们还描述了化学方法可能会找到应用方向的心脏修复和再生的新方向。
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