Goodman J H, Homan R W, Crawford I L
Department of Neurology, University of Texas Southwestern Medical Center, Dallas.
Epilepsia. 1990 Sep-Oct;31(5):489-95. doi: 10.1111/j.1528-1157.1990.tb06096.x.
The effect of kindled seizures on the cardiovascular system was examined in amygdaloid kindled rats. The most prominent cardiovascular response during a generalized kindled seizure was an abrupt 50% increase in mean arterial pressure (MAP) lasting 20-30 s after initiation of the seizure. Superimposed on this change in blood pressure (BP) was a profound bradycardia characterized by a rate about half that recorded before stimulation. Changes in heart rate (HR) and BP observed during amygdaloid kindled seizures were similar to those observed during secondary spontaneous seizures. These effects apparently are independent of the kindling stimulus because stimulus-induced cardiovascular changes were not present at the beginning of the kindling process. These results suggest that the kindling seizure model is useful to study the underlying mechanisms of seizure-induced cardiac arrhythmias and possibly the clinical phenomenon of sudden unexplained death in epileptic patients.
在杏仁核点燃大鼠中研究了点燃性癫痫发作对心血管系统的影响。在全身性点燃性癫痫发作期间，最显著的心血管反应是癫痫发作开始后平均动脉压（MAP）突然升高50%，持续20 - 30秒。叠加在这种血压（BP）变化之上的是严重的心动过缓，其特征是心率约为刺激前记录心率的一半。在杏仁核点燃性癫痫发作期间观察到的心率（HR）和血压变化与继发性自发性癫痫发作期间观察到的变化相似。这些效应显然与点燃刺激无关，因为在点燃过程开始时不存在刺激诱导的心血管变化。这些结果表明，点燃性癫痫发作模型有助于研究癫痫发作诱发心律失常的潜在机制，以及可能有助于研究癫痫患者不明原因猝死的临床现象。
