Harris Q L, Lewis S J, Shulkes A, Vajda F J, Jarrott B
University of Melbourne, Austin Hospital, Victoria, Australia.
Neuropharmacology. 1988 May;27(5):547-50. doi: 10.1016/0028-3908(88)90139-6.
In an attempt to understand the neurochemical basis of kindling, this study investigated the effects on brain cholecystokinin (CCK) of amygdaloid kindled and non-kindled seizures. Thirteen brain regions were examined in rats sacrificed either 24 hr or 3 weeks after the last kindled seizure, or 24 hr after a suprathreshold stimulation-induced (non-kindled) seizure; and in sham kindled rats. There were no significant differences in CCK immunoreactivity between any of these groups. These results do not confirm a previous report of an increase in CCK in the hippocampus following amygdaloid kindling in the rat.
为了理解点燃效应的神经化学基础，本研究调查了杏仁核点燃性和非点燃性癫痫发作对脑胆囊收缩素（CCK）的影响。在末次点燃性癫痫发作后24小时或3周、阈上刺激诱发（非点燃性）癫痫发作后24小时处死的大鼠以及假点燃大鼠中，检测了13个脑区。这些组之间的CCK免疫反应性没有显著差异。这些结果并未证实先前关于大鼠杏仁核点燃后海马中CCK增加的报道。
