里程碑系列：小肠神经内分泌肿瘤的管理
The Landmark Series: Management of Small Bowel Neuroendocrine Tumors.
作者信息
Tran Catherine G, Sherman Scott K, Howe James R
机构信息
Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
出版信息
Ann Surg Oncol. 2021 May;28(5):2741-2751. doi: 10.1245/s10434-020-09566-4. Epub 2021 Jan 15.
Abstract
Surgical resection is the foundation for treatment of small bowel neuroendocrine tumors (SBNETs). Guidelines for surgical management of SBNETs rely on retrospective data, which suggest that primary tumor resection and cytoreduction improve symptoms, prevent future complications, and lengthen survival. In advanced NETs, improvement in progression-free survival has been reported in large, randomized, controlled trials of various medical treatments, including somatostatin analogues, targeted therapy, and peptide receptor radionuclide therapy. This review discusses important studies influencing the management of SBNETs and the limitations of current evidence regarding surgical interventions for SBNETs.
摘要
手术切除是小肠神经内分泌肿瘤（SBNETs）治疗的基础。SBNETs的手术管理指南依赖于回顾性数据，这些数据表明原发性肿瘤切除和减瘤可改善症状、预防未来并发症并延长生存期。在晚期神经内分泌肿瘤（NETs）中，在包括生长抑素类似物、靶向治疗和肽受体放射性核素治疗在内的各种药物治疗的大型随机对照试验中，已报道无进展生存期有所改善。本综述讨论了影响SBNETs管理的重要研究以及当前关于SBNETs手术干预证据的局限性。
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