University of Washington, Department of Psychiatry and Behavioral Sciences, Seattle, WA, USA; Fred Hutchinson Cancer Research Center, USA.
Life Sci. 2013 Oct 17;93(17):617-22. doi: 10.1016/j.lfs.2013.08.011. Epub 2013 Sep 5.
The second most frequently reported post-treatment symptom in cancer survivors are concerns about impaired cognition. Despite numerous studies demonstrating significant impairments in a portion of survivors, information on effective treatments remains an emerging area of research. This study examined the effectiveness of a group-based cognitive rehabilitation intervention in cancer survivors.
This study was a randomized, controlled study of a 7-week cognitive rehabilitation intervention delivered in group format. Participants were evaluated with subjective symptom questionnaires and objective neurocognitive tests prior to and following treatment.
Twenty-eight participants (mean age 58 years) with a median of 3 years (± 6 years) post-primary/adjuvant treatment and various cancer sites (breast, bladder, prostate, colon, uterine) completed the study. Compared to baseline, the treatment group demonstrated improvements in symptoms of perceived cognitive impairments (p<.01), cognitive abilities (p<.01) and overall quality of life with regard to cognitive symptoms (p<.01) as measured by the FACT-Cog. The treatment group also improved on objective measures of attention (p<.05) and a trend toward improvement on verbal memory. Significant improvement was not observed on all cognitive tests.
A group based cognitive rehabilitation intervention in cancer survivors was effective for improving attention abilities and overall quality of life related to cognition. Results suggest that group based cognitive rehabilitation may be an effective intervention for treating cognitive dysfunction in cancer patients and should be further studied in a larger trial with an active control condition.
癌症幸存者报告的第二常见治疗后症状是对认知受损的担忧。尽管有许多研究表明一部分幸存者存在明显的认知障碍，但有效的治疗信息仍然是一个新兴的研究领域。本研究旨在检验基于群体的认知康复干预对癌症幸存者的有效性。
这是一项为期 7 周的认知康复干预的随机对照研究，以小组形式进行。在治疗前后，参与者使用主观症状问卷和客观神经认知测试进行评估。
28 名参与者（平均年龄 58 岁）中位随访时间为治疗后 3 年（±6 年），癌症部位包括乳腺、膀胱、前列腺、结肠和子宫。与基线相比，治疗组在感知认知障碍症状（p<.01）、认知能力（p<.01）和认知症状相关的整体生活质量（p<.01）方面的改善明显。FACT-Cog 评估显示，治疗组的注意力（p<.05）也有所改善，且在言语记忆方面有改善的趋势。但并非所有认知测试都有显著改善。
基于群体的认知康复干预对癌症幸存者有效，可以改善注意力和与认知相关的整体生活质量。结果表明，基于群体的认知康复可能是治疗癌症患者认知功能障碍的有效干预措施，应在更大的、有对照的试验中进一步研究。
