Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Tilburg, The Netherlands.
Expert Rev Anticancer Ther. 2010 Nov;10(11):1779-95. doi: 10.1586/era.10.163.
Patients with brain tumors may suffer from cognitive deficits caused by the disease and/or its treatment. Here, we review recent efforts in the research on prevention or treatment of cognitive deficits in these patients. We conclude that interest in this area is growing, but that methodological difficulties persist. In addition, we describe the recently completed first randomized controlled trial on the effectiveness of cognitive rehabilitation that we conducted in patients with brain cancer. By reflecting on the methodological challenges experienced in our trial, we hope to assist others in planning and conducting future studies on both pharmacological treatments and cognitive rehabilitation programs for cognitive deficits in this patient population. We conclude with suggestions for future research directions.
脑肿瘤患者可能会因疾病和/或治疗而出现认知缺陷。在这里，我们回顾了近期在预防或治疗这些患者认知缺陷方面的研究进展。我们的结论是，人们对这一领域的兴趣正在增加，但方法学方面的困难仍然存在。此外，我们还描述了我们最近在脑癌患者中完成的关于认知康复有效性的首个随机对照试验。通过反思我们试验中遇到的方法学挑战，我们希望能帮助其他人规划和开展针对该患者群体认知缺陷的药物治疗和认知康复方案的未来研究。最后，我们提出了未来研究方向的建议。
