School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Life Sci. 2013 Oct 10;93(15):487-94. doi: 10.1016/j.lfs.2013.08.012. Epub 2013 Sep 5.
Histamine is a biogenic amine that plays an essential role in controlling many physiological functions, both in the central nervous system (CNS) and the peripheral nervous system (PNS). Most of these physiological effects are mediated through interactions with four histamine receptor subtypes, all of which are members of the larger family of rhodopsin-like class A G-protein coupled receptors (GPCRs) (Leurs et al., 2011; Lim et al., 2009). Here, we focus on the genetic variations and polymorphisms localized on the genes encoding for human histamine receptors where it provides an up to date collection of all polymorphisms found on genes encoding the histamine receptor subtypes and their association to diseases.
组胺是一种生物胺，在中枢神经系统（CNS）和周围神经系统（PNS）中对控制许多生理功能都起着至关重要的作用。这些生理作用主要通过与四种组胺受体亚型相互作用来介导，所有这些受体亚型都是更大的视紫红质样 A 类 G 蛋白偶联受体（GPCR）家族的成员（Leurs 等人，2011 年；Lim 等人，2009 年）。在这里，我们重点介绍了位于编码人类组胺受体的基因上的遗传变异和多态性，这些变异和多态性提供了编码组胺受体亚型的基因上所有发现的多态性及其与疾病的关联的最新信息。
