Guo Jing-Ke, Xu Ming-Ming, Zheng Mei-Feng, Liu Shu-Tao, Zhou Jian-Wu, Ke Li-Jing, Chen Tian-Bao, Rao Ping-Fan
SIBS, CAS-Zhejiang Gongshang University Joint Centre for Food and Nutrition Research, Zhejiang Gongshang University, Hangzhou 310018, China.
Acupuncture College, Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China.
Evid Based Complement Alternat Med. 2016;2016:3830273. doi: 10.1155/2016/3830273. Epub 2016 Dec 29.
Reactive oxygen species are products of cellular metabolism and assigned important roles in biomedical science as deleterious factors in pathologies. In fact, some studies have shown that the therapeutic benefits of taking antioxidants were limited and the potential for therapeutic intervention remains unclear. New evidences showed that ROS have some ability of intercellular transportation. For treating allergic rhinitis, as a novel intracellular superoxide quencher, TAT-SOD applied to acupoints LI 20 instead of directly to nasal cavity can be used to test that. TTA group apply TAT-SOD cream prepared by adding purified TAT-SOD to the vehicle cream to acupoints LI 20, while placebo group used the vehicle cream instead. TTN group applied the same TAT-SOD cream directly to nasal cavity three times daily. Symptom scores were recorded at baseline and days 8 and 15. For the overall efficacy rate, TTA group was 81.0%, while placebo group was 5.9% and TTN was 0%. Malondialdehyde levels decreased observably in TTA group, and superoxide dismutase, catalase, and glutathione peroxidase levels remained basically unaffected. Enzymatic scavenging of the intracellular superoxide at acupoints LI 20 proved to be effective in treating allergic rhinitis, while no improvement was observed with the placebo group and TTN group.
活性氧是细胞代谢的产物，在生物医学中作为病理过程中的有害因素发挥着重要作用。事实上，一些研究表明服用抗氧化剂的治疗益处有限，治疗干预的潜力仍不明确。新证据表明活性氧具有一定的细胞间运输能力。为了治疗过敏性鼻炎，作为一种新型的细胞内超氧化物清除剂，应用于穴位LI 20而非直接用于鼻腔的TAT-SOD可用于对此进行测试。TTA组将通过向赋形剂乳膏中添加纯化的TAT-SOD制备的TAT-SOD乳膏应用于穴位LI 20，而安慰剂组则使用赋形剂乳膏。TTN组将相同的TAT-SOD乳膏每天直接涂抹于鼻腔三次。在基线以及第8天和第15天记录症状评分。对于总有效率，TTA组为81.0%，而安慰剂组为5.9%，TTN组为0%。TTA组丙二醛水平明显降低，而超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶水平基本未受影响。事实证明，在穴位LI 20对细胞内超氧化物进行酶清除对治疗过敏性鼻炎有效，而安慰剂组和TTN组未观察到改善。
