Faculté des Sciences de la Vie, Université de Strasbourg, Strasbourg, France; UPR9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
Dev Comp Immunol. 2014 Jan;42(1):3-15. doi: 10.1016/j.dci.2013.08.018. Epub 2013 Sep 4.
The functional analysis of genes from the model organism Drosophila melanogaster has provided invaluable information for many cellular and developmental or physiological processes, including immunity. The best-understood aspect of Drosophila immunity is the inducible humoral response, first recognized in 1972. This pioneering work led to a remarkable series of findings over the next 30 years, ranging from the identification and characterization of the antimicrobial peptides produced, to the deciphering of the signalling pathways activating the genes that encode them and, ultimately, to the discovery of the receptors sensing infection. These studies on an insect model coincided with a revival of the field of innate immunity, and had an unanticipated impact on the biomedical field.
黑腹果蝇模型生物的基因功能分析为许多细胞和发育或生理过程（包括免疫）提供了宝贵的信息。黑腹果蝇免疫的最佳研究方面是可诱导的体液反应，该反应于 1972 年首次被发现。这项开创性的工作在接下来的 30 年中产生了一系列显著的发现，从鉴定和描述产生的抗菌肽，到阐明激活编码它们的基因的信号通路，最终发现了感知感染的受体。这些在昆虫模型上的研究恰逢先天免疫领域的复兴，并对生物医学领域产生了意外的影响。
