Cammarata-Mouchtouris Alexandre, Acker Adrian, Goto Akira, Chen Di, Matt Nicolas, Leclerc Vincent
Institut de Biologie Moléculaire et Cellulaire (IBMC), UPR9022, CNRS, Université de Strasbourg, 67084 Strasbourg, France.
Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China.
Biomedicines. 2022 Sep 16;10(9):2304. doi: 10.3390/biomedicines10092304.
Metazoans have developed strategies to protect themselves from pathogenic attack. These preserved mechanisms constitute the immune system, composed of innate and adaptive responses. Among the two kinds, the innate immune system involves the activation of a fast response. NF-κB signaling pathways are activated during infections and lead to the expression of timely-controlled immune response genes. However, activation of NF-κB pathways can be deleterious when uncontrolled. Their regulation is necessary to prevent the development of inflammatory diseases or cancers. The similarity of the NF-κB pathways mediating immune mechanisms in insects and mammals makes a suitable model for studying the innate immune response and learning general mechanisms that are also relevant for humans. In this review, we summarize what is known about the dynamic regulation of the central NF-κB-pathways and go into detail on the molecular level of the IMD pathway. We report on the role of the nuclear protein Akirin in the regulation of the NF-κB Relish immune response. The use of the model allows the understanding of the fine-tuned regulation of this central NF-κB pathway.
后生动物已经发展出保护自己免受病原体攻击的策略。这些保留下来的机制构成了免疫系统，由先天免疫和适应性免疫反应组成。在这两种免疫反应中，先天免疫系统涉及快速反应的激活。NF-κB信号通路在感染期间被激活，并导致及时控制的免疫反应基因的表达。然而，NF-κB通路的激活如果不受控制可能是有害的。对其进行调控对于预防炎症性疾病或癌症的发展是必要的。昆虫和哺乳动物中介导免疫机制的NF-κB通路的相似性使其成为研究先天免疫反应以及了解对人类也相关的一般机制的合适模型。在这篇综述中，我们总结了关于核心NF-κB通路动态调控的已知信息，并在分子水平上详细探讨了IMD通路。我们报告了核蛋白Akirin在NF-κB Relish免疫反应调控中的作用。使用该模型有助于理解这条核心NF-κB通路的精细调控。
