Women's Health and Exercise Laboratory and the Department of Kinesiology, Pennsylvania State University, University Park, PA 16802, United States.
Peptides. 2013 Nov;49:81-90. doi: 10.1016/j.peptides.2013.08.018. Epub 2013 Sep 3.
Peptide YY (PYY) and ghrelin exhibit a reciprocal association and antagonistic physiological effects in the peripheral circulation. Research has yet to clarify the effect of weight loss on the 24h profile of PYY or its association to 24h ghrelin. We sought to determine if diet- and exercise-induced weight loss affects the 24h profile of PYY and its association with 24h ghrelin in normal weight, premenopausal women. Participants (n = 13) were assessed at baseline (BL) and after a 3-month diet and exercise intervention (post). Blood samples obtained q10 min for 24h were assayed for total PYY and total ghrelin q60 min from 0800 to 1000 h and 2000 to 0800 h and q20 min from 1000 to 2000 h. The ghrelin/PYY ratio was used as an index of hormonal exposure. Statistical analyses included paired t-tests and linear mixed effects modeling. Body weight (-1.85 ± 0.67 kg; p = 0.02), and body fat (-2.53 ± 0.83%; p = 0.01) decreased from BL to post. Ghrelin AUC (5252 ± 2177 pg/ml/24h; p=0.03), 24h mean (216 ± 90 pg/ml; p = 0.03) and peak (300 ± 134 pg/ml; p = 0.047) increased from BL to post. No change occurred in PYY AUC (88.2 ± 163.7 pg/ml; p = 0.60), 24h mean (4.8 ± 6.9 pg/ml; p = 0.50) or peak (3.6 ± 6.4 pg/ml; p = 0.58). The 24h association between PYY and ghrelin at baseline (p = 0.04) was weakened at post (p = 0.14); however, the ghrelin/PYY lunch ratio increased (p = 0.01) indicating the potential for ghrelin predominance over PYY in the circulation. PYY and ghrelin are reciprocally associated during a period of weight stability, but not following weight loss. An "uncoupling" may have occurred, particularly at lunch, due to factors that modulate ghrelin in response to weight loss.
肽 YY（PYY）和胃饥饿素在外周循环中表现出相互关联和拮抗的生理作用。研究尚未阐明减肥对 PYY 的 24 小时谱及其与 24 小时胃饥饿素的关联的影响。我们试图确定饮食和运动引起的体重减轻是否会影响正常体重、绝经前女性的 PYY 的 24 小时谱及其与 24 小时胃饥饿素的关联。参与者（n = 13）在基线（BL）和 3 个月饮食和运动干预后（post）进行评估。从 0800 到 1000 h 和 2000 到 0800 h，每 10 min 采集一次血液样本，从 1000 到 2000 h，每 20 min 采集一次血液样本，共采集 24 h，检测总 PYY 和总胃饥饿素。胃饥饿素/ PYY 比值用作激素暴露的指标。统计分析包括配对 t 检验和线性混合效应模型。体重（-1.85 ± 0.67 kg；p = 0.02）和体脂（-2.53 ± 0.83%；p = 0.01）从 BL 到 post 下降。胃饥饿素 AUC（5252 ± 2177 pg/ml/24h；p=0.03）、24h 均值（216 ± 90 pg/ml；p = 0.03）和峰值（300 ± 134 pg/ml；p = 0.047）从 BL 到 post 增加。PYY AUC 无变化（88.2 ± 163.7 pg/ml；p = 0.60）、24h 均值（4.8 ± 6.9 pg/ml；p = 0.50）或峰值（3.6 ± 6.4 pg/ml；p = 0.58）。基线时 PYY 和胃饥饿素的 24h 相关性（p = 0.04）在 post 时减弱（p = 0.14）；然而，胃饥饿素/ PYY 午餐比值增加（p = 0.01），表明在循环中，胃饥饿素对 PYY 的优势可能增加。PYY 和胃饥饿素在体重稳定期间呈相互关联，但在减肥后则不然。由于调节胃饥饿素对体重减轻反应的因素，可能发生了“解耦”，特别是在午餐时。
