Lipsky H
Department of Urology, Landeskrankenhaus, Leoben, Austria.
Eur Urol. 1990;18(1):52-5. doi: 10.1159/000463867.
A submucosal injection with bovine collagen (Zyplast) was performed in 45 female patients with 70 refluxing ureters. 4 ureters showed reflux grade IV, while the others had reflux grade I-III. All patients suffered from recurrent urinary tract infections. In 18 ureters, a second injection was given. As a result of this treatment, reflux was cured in 85.8% of the ureters. Only 13 patients had urinary tract infections during the follow-up period (6-24 months). 5 patients had antireflux surgery and collagen was excised. The histology of the specimen did not show an inflammatory reaction. Collagen injections could gain great importance in the management of vesicoureteral reflux.
对45例患有70条反流输尿管的女性患者进行了牛胶原蛋白（Zyplast）黏膜下注射。4条输尿管显示为IV级反流，其余输尿管为I - III级反流。所有患者均患有复发性尿路感染。对18条输尿管进行了第二次注射。经过这种治疗，85.8%的输尿管反流得到治愈。在随访期（6 - 24个月）内，只有13例患者发生尿路感染。5例患者接受了抗反流手术并切除了胶原蛋白。标本的组织学检查未显示炎症反应。胶原蛋白注射在膀胱输尿管反流的治疗中可能具有重要意义。
